1,2-Benzisothiazol-3(2H)-one

Substance overview Plus
Name:
1,2-Benzisothiazol-3(2H)-one
CAS Number:
2634-33-5
Synonyms:
1,2-Benzisothiazolin-3-one, BIT
Approval number:
Does not have an individual approval but may be used under an appropriate group standard
UN Class:
 
UN Number:
 
Molecular weight:
151.1826
Relative density:
 
Water solubility:
 
Classification Acute Tox. 4 Plus
Classification route species:
(oral)
Classification description:
H302: Harmful if swallowed.
Classification key study:

Oral Route
SPECIES: Rats
ENDPOINT: LD50
VALUE: 1020 mg/kg
REFERENCE SOURCE: Nordic Chemicals Group Health effects of selected chemicals 2. 1,2-Benzisothiazolin-3(2H)-one Nord PG:9-23 YR:1993 IP: VI:29 [TOXLINE]
REMARK: No acute toxic effects have been observed in humans.

Classification Skin Irrit. 2 Plus
Classification route species:
 
Classification description:
H315: Causes skin irritation.
Classification key study:

Skin Irritation
SPECIES:
RESULT: Commercial products containing BIT appears to have corrosive properties with risk of severe skin damage. However, in humans it appear that BlT is less potent when applied on the skin.
REFERENCE SOURCE: Nordic Chemicals Group Health effects of selected chemicals 2. 1,2-Benzisothiazolin-3(2H)-one Nord PG:9-23 YR:1993 IP: VI:29 [toxline]
NOTE: Skin irritant at 20% and above [ECB ANNEX1]

Eye Irritation
R PHRASE: R 41[IUCLID 2000]
REMARK: Eye corrosive at 10% and above [ECB - ANNEX I]

Classification Eye Damage 1 Plus
Classification route species:
 
Classification description:
H318: Causes serious eye damage.
Classification key study:

Skin Irritation
SPECIES:
RESULT: Commercial products containing BIT appears to have corrosive properties with risk of severe skin damage. However, in humans it appear that BlT is less potent when applied on the skin.
REFERENCE SOURCE: Nordic Chemicals Group Health effects of selected chemicals 2. 1,2-Benzisothiazolin-3(2H)-one Nord PG:9-23 YR:1993 IP: VI:29 [toxline]
NOTE: Skin irritant at 20% and above [ECB ANNEX1]

Eye Irritation
R PHRASE: R 41[IUCLID 2000]
REMARK: Eye corrosive at 10% and above [ECB - ANNEX I]

Classification Skin Sens. 1 Plus
Classification route species:
 
Classification description:
H317: May cause an allergic skin reaction.
Classification key study:
Contact Sensitisation
R PHRASE: R 43. [ECB]
NOTE: Sensitiser (6.5B) down to 0.05% [ECB]
Contact Sensitisation: Effects Below Cut Off
Classification Specific concentration limits Plus
Classification route species:
 
Classification description:
 
Classification key study:
Concentration range (%): >= 10
Hazard categories: Eye Damage 1
Classification Specific concentration limits Plus
Classification route species:
 
Classification description:
 
Classification key study:
Concentration range (%): >= 5 < 10
Hazard categories: Eye Irrit. 2
Classification Specific concentration limits Plus
Classification route species:
 
Classification description:
 
Classification key study:
Concentration range (%): >= 20
Hazard categories: Skin Irrit. 2
Classification Specific concentration limits Plus
Classification route species:
 
Classification description:
 
Classification key study:
Concentration range (%): >= 0.05
Hazard categories: Skin Sens. 1
Classification Aquatic Acute 1 Plus
Classification route species:
 
Classification description:
H400: Very toxic to aquatic life.
Classification key study:
Bioaccumulation: Bioaccumulative: No
Estimated LogKow = 0.6368 (USEPA KOWWIN)
Biodegradation in water: not biodegradable
Short term toxicity to fish: SPECIES: Rainbow Trout (Oncorhynchus mykiss)
TYPE OF EXPOSURE: Flow through
DURATION: 96 hr
ENDPOINT: LC50
VALUE: 1.6 PPM (= 1.6 mg/l)
REFERENCE SOURCE: date 1979, code 41687101[OPP pesticide ecotox dbase]

Short term toxicity to invertebrates: SPECIES: Daphnia Magna (Water Flea)
TYPE OF EXPOSURE: Static
DURATION: 48 hr
ENDPOINT: EC50
VALUE: 1.1 PPM (= 1.1 mg/l)
REFERENCE SOURCE date 1977, code 00133876
[OPP pesticide ecotox dbase]

Toxicity to freshwater algae and cyanobacteria: SPECIES: Green algae
TYPE OF EXPOSURE:
DURATION: 72 hr
ENDPOINT: EC50
RESULT: 0.15 mg/L
REFERENCE SOURCE: Danish EPA. 2001 Environmental and Health Assessment of Substances in Household Detergents and Cosmetic Detergent Products Environment Project no615.
Classification Aquatic Chronic 1 Plus
Classification route species:
 
Classification description:
H410: Very toxic to aquatic life with long lasting effects.
Classification key study:
Bioaccumulation: Bioaccumulative: No
Estimated LogKow = 0.6368 (USEPA KOWWIN)
Biodegradation in water: not biodegradable
Toxicity to freshwater algae and cyanobacteria: SPECIES: Green algae
TYPE OF EXPOSURE:
DURATION: 72 hr
ENDPOINT: EC50
RESULT: 0.15 mg/L
REFERENCE SOURCE: Danish EPA. 2001 Environmental and Health Assessment of Substances in Household Detergents and Cosmetic Detergent Products Environment Project no615.