Propham

Substance overview Plus
Name:
Propham
CAS Number:
122-42-9
Synonyms:
Carbamic acid, phenyl-, 1-methylethyl ester, Isopropyl phenylcarbamate
Approval number:
Does not have an individual approval but may be used under an appropriate group standard
UN Class:
 
UN Number:
 
Molecular weight:
179.21
Relative density:
1.09
Water solubility:
32 mg/L
Classification Eye Irrit. 2 Plus
Classification route species:
 
Classification description:
H319: Causes serious eye irritation.
Classification key study:

Eye Irritation
SPECIES: Rabbit
RESULT: Moderate irritant
REFERENCE SOURCE: [APVMA review 1997]

Classification STOT Rep. Exp. 2 Plus
Classification route species:
 
Classification description:
H373: May cause damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
Classification key study:
Repeated dose toxicity:

Oral Route
Primary Organ Effected: Blood and the Hematopoietic system
Secondary Organ(s) Effected: Hepatotoxicity (liver)
Respiratory system
Long-term toxicity/carcinogenicity studies
Rats
Four groups of 20 SPF Wistar rats (Bor strain, WISW/SPF Cpb)/sex, 4 to 5 weeks old, and weighing 72 to 110 g (males) or 73 to 107 g (females) were fed dietary concentrations (99.3% purity propham) of 0, 100, 500 or 2500 ppm equal to 0, 5.7, 29 or 150 mg/kg bw/day for males and 7.6, 37 or 200 mg/kg bw/day for females, for 24 months. Ten additional rats/sex/dose level were fed similar diets and were sacrificed at 12 months. Homogeneity based on diet containing 100 or 15 000 ppm was within ±10% and stability under conditions of storage similar to those used in the present study indicated 101 to 109% of initial concentrations. Body-weight, food and water intake were monitored weekly up to week 13 and biweekly thereafter. Haematology, clinical biochemistry, urinalysis, and ophthalmoscopy were performed and gross pathological examinations and histopathological examinations were carried out. No treatment- related incidences of clinical signs and symptoms, changes in food and water intake or mortality were observed up to the dosage of 2500 ppm. Body-weight gain was comparable to control rats up to 2500 ppm (males) and 500 ppm (females). At 2500 ppm, weight gain was slightly decreased in females during the second half of the study. No evidence of any treatment-related adverse effects on the blood or haematopoietic organs was found in the 100 ppm dosage group. At and above 500 ppm, evidence of increased haemopoiesis was observed in the spleen and liver. Reduced erythrocyte and haematocrit counts and increased spleen weights were also recorded in the 2500 ppm groups. At 2500 ppm mineralization in the kidneys and increased relative kidney weights were observed most often in the females. No adverse effects were noted for any other organ systems. Ophthalmological investigations revealed age-related eye changes which were fairly evenly distributed over all groups. No carcinogenic potential of propham could be inferred from the type, frequency or time of onset of benign or malignant tumours. Based on the effects on the blood parameters, a NOAEL for propham of 100 ppm, equal to 5.7 and 7.6 mg/kg bw/day in males and females respectively was determined. Carcinogenicity was not demonstrated (Eiben, 1989).
[INCHEM, Pesticides residues in food 1992]

Classification Aquatic Chronic 2 Plus
Classification route species:
 
Classification description:
H411: Toxic to aquatic life with long lasting effects.
Classification key study:
Bioaccumulation: Bioaccumulative: No
Log Kow = 2.6
Toxicity to freshwater algae and cyanobacteria: Chronic Endpoint: [other]
Chronic Value: 10 mg/L
SPECIES: Chlorella green algae
TYPE OF EXPOSURE:
DURATION: 96 hr
ENDPOINT: LOEC
VALUE: 10000 ug/L (= 10 mg/l)
REFERENCE SOURCE: Ref no: 19243. Garten, C.T.J. (1990) Multispecies Methods of Testing for Toxicity: Use of the Rhizobium-Legume Symbiosis in Nitrogen Fixation and Correlations Between Responses by Algae and Terrestrial Plants. In: W.Wang, J.W.Gorsuch, and W.R.Lower (Eds.), Plants for Toxicity Assessment, ASTM STP 1091, Philadelphia, PA :69-84
Classification Hazardous to soil organisms Plus
Classification route species:
 
Classification description:
 
Classification key study: