Silica, crystalline (quartz)

Substance overview Plus
Name:
Silica, crystalline (quartz)
CAS Number:
14808-60-7
Synonyms:
Rock crystal
Approval number:
HSR003125
UN Class:
 
UN Number:
 
Molecular weight:
60.08
Relative density:
 
Water solubility:
 
Classification 6.7A Plus
Classification route species:
 
Classification description:
Known or presumed human carcinogens
Classification key study:
REMARK: In making the overall evaluation, the Working Group noted that carcinogenicity in humans was not detected in all industrial circumstances studied. Carcinogenicity may be dependent on inherent characteristics of the crystalline silica or on external factors affecting its biological activity or distribution of its polymorphs. Crystalline silica inhaled in the form of quartz or cristobalite from occupational sources is carcinogenic to humans (Group 1).
REFERENCE SOURCE: [IARC Vol.: 68 (1997) (p. 41)]

EXPERT JUDGEMENT: This substance only triggers 6.7A if it is in the form of a fine respirable dust in an occupational (chronic exposure) setting.
Note: This substance is non hazardous if it is not a fine respirable dust.
Classification 6.9A (All) Plus
Classification route species:
(All)
Classification description:
Toxic to human target organs or systems
Classification key study:
 
Classification 6.9A (I) Plus
Classification route species:
(inhalation)
Classification description:
Toxic to human target organs or systems
Classification key study:
EndPoint:
Primary Organ:
SPECIES: Rat
EXPOSURE: for up to 420 days
FREQUENCY OF TREATMENT: 18hrs/day 5days/week
DOSES: 30000 particles (40%<0.5 microns) per ml
REMARK: Similar findings have also been reported in rats, guinea pigs, rabbits and monkeys. After periods of exposure by inhalation varying from on to two weeks.
RESULT: By 220 days: silicotic nodules, showing only reticulin fibosis had developed.
By 300 days: dense, rouded collagenous nodules were present.
REFERENCE SOURCE: SIRO S.P.A. ROBILANTE [IUCLID 2000]

EXPERT JUDGEMENT: This substance only triggers 6.9A if it is in the form of a fine respirable dust in an occupational (chronic exposure) setting.
Note: This substance is non hazardous if it is not a fine respirable dust.