Zinc chromate

Substance overview Plus
Name:
Zinc chromate
CAS Number:
13530-65-9
Synonyms:
Chromic acid (H2CrO4), zinc salt (1:1), Zinc Chrome Yellow, Zinc chromate(VI) hydroxide
Approval number:
HSR003960, Approved with controls
UN Class:
Class 6: Toxic and infectious substances; Division 6.1; Packing group II: Substances presenting medium danger
UN Number:
3288
Molecular weight:
181.37
Relative density:
3.4
Water solubility:
 
Classification Acute Tox. 4 Plus
Classification route species:
(oral)
Classification description:
H302: Harmful if swallowed.
Classification key study:

Oral Route
R-PHRASE: R 22 [N-Class]

Classification Skin Corr. 1C Plus
Classification route species:
 
Classification description:
H314: Causes severe skin burns and eye damage.
Classification key study:

Skin Irritation
REMARK: Zinc chromate can irritate the skin causing a rash or skin ulcers. Bloomfield & Blum, 1928
REFERENCE SOURCE: [INCHEM]
EXPERT JUDGEMENT: Skin ulcers would suggest corrosive properties of this substance.

Classification Skin Sens. 1 Plus
Classification route species:
 
Classification description:
H317: May cause an allergic skin reaction.
Classification key study:
Contact Sensitisation
R-PHRASE: R43. [INCHEM]
Classification Muta. 1 Plus
Classification route species:
 
Classification description:
H340: May cause genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
Classification key study:
Genetic toxicity in Vitro: Chromium[VI] compounds of various solubilities in water were consistently active in numerous studies covering a wide range of tests for genetic and related effects. In particular, potassium dichromate, sodium dichromate, ammonium dichromate, potassium chromate, sodium chromate, ammonium chromate, chromium trioxide, calcium chromate, strontium chromate and zinc yellow induced a variety of effects (including DNA damage, gene mutation, sister chromatid exchange, chromosomal aberrations, cell transformation and dominant lethal mutation) in a number of targets, including animal cells in vivo and animal and human cells in vitro. Potassium chromate induced aneuploidy in insects, while chromium trioxide did not; various compounds induced gene mutation in insects. Potassium dichromate produced recombination, gene mutation and aneuploidy in fungi. All of these chromium[VI] compounds induced DNA damage and gene mutation in bacteria. Similar patterns were observed with zinc chromate, barium chromate, lead chromate and the derived pigments chromium orange, chromium yellow and molybdenum orange, which, however, often required preliminary dissolution in alkali or acids. A liquid chromium[VI] compound (chromyl chloride) and its vapours induced gene mutation in bacteria.
[IARC]
Genetic toxicity in Vivo: Chromium[VI] compounds of various solubilities in water were consistently active in numerous studies covering a wide range of tests for genetic and related effects. In particular, potassium dichromate, sodium dichromate, ammonium dichromate, potassium chromate, sodium chromate, ammonium chromate, chromium trioxide, calcium chromate, strontium chromate and zinc yellow induced a variety of effects (including DNA damage, gene mutation, sister chromatid exchange, chromosomal aberrations, cell transformation and dominant lethal mutation) in a number of targets, including animal cells in vivo and animal and human cells in vitro. Potassium chromate induced aneuploidy in insects, while chromium trioxide did not; various compounds induced gene mutation in insects. Potassium dichromate produced recombination, gene mutation and aneuploidy in fungi. All of these chromium[VI] compounds induced DNA damage and gene mutation in bacteria. Similar patterns were observed with zinc chromate, barium chromate, lead chromate and the derived pigments chromium orange, chromium yellow and molybdenum orange, which, however, often required preliminary dissolution in alkali or acids. A liquid chromium[VI] compound (chromyl chloride) and its vapours induced gene mutation in bacteria.
[IARC]
Classification Carc. 1 Plus
Classification route species:
 
Classification description:
H350: May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
Classification key study:
Key information: Chromium[VI] is carcinogenic to humans (Group 1).
[IARC]

Classification Aquatic Acute 1 Plus
Classification route species:
 
Classification description:
H400: Very toxic to aquatic life.
Classification key study:
Biodegradation in water: not biodegradable
Short term toxicity to fish: R-PHRASE: R50-53. [INCHEM]

Short term toxicity to invertebrates: R-PHRASE: R 50-53. [INCHEM]
Toxicity to freshwater algae and cyanobacteria: R-PHRASE: R 50-53. [INCHEM]
Classification Aquatic Chronic 1 Plus
Classification route species:
 
Classification description:
H410: Very toxic to aquatic life with long lasting effects.
Classification key study:
Biodegradation in water: not biodegradable
Toxicity to freshwater algae and cyanobacteria: R-PHRASE: R 50-53. [INCHEM]