1,2-Ethanediol (ethylene glycol)

Substance overview Plus
Name:
1,2-Ethanediol (ethylene glycol)
CAS Number:
107-21-1
Synonyms:
1,2 Ethanediol, 1,2-Dihydroxyethane, 1,2-Ethanediol, 1,2-Ethylene glycol, 2-Hydroxyethanol, Ethylene alcohol, Ethylene dihydrate, Monoethylene glycol, Ethylene glycol
Approval number:
HSR001534, Approved with controls
UN Class:
 
UN Number:
 
Molecular weight:
62.07
Relative density:
1.1088
Water solubility:
1000000.0 mg/L
Classification Acute Tox. 4 Plus
Classification route species:
(oral)
Classification description:
H302: Harmful if swallowed.
Classification key study:
Dose Descriptor: LD50
Value: 1670 mg/kg bw

Oral Route
SPECIES: Cat
ENDPOINT: LD50
VALUE: 1670 mg/kg bw
REFERENCE SOURCE: Hoechst AG Frankfurt/Main Hoechst AG Frankfurt/Main, Clariant GmbH Frankfurt am Main (268) Moraillon, Pinault (1978): Rec. Med. Vet. 154, 137-150 [IUCLID 2000]

Dermal Route
Toxicity Values from NTP health and safety section
TOXICITY
========
*NIOSH REGISTRY NUMBER: KW2975000
*TOXICITY:
Typ. dose mode specie amount units other
LD50 skn rbt 9530 mg/kg
All from the NTP CATALOG ID Number: 000103
[NTP]

Classification Eye Irrit. 2 Plus
Classification route species:
 
Classification description:
H319: Causes serious eye irritation.
Classification key study:

Skin Irritation
Ethylene glycol does not significantly irritate the skin. Slight maceration of the skin may result from very severe, prolonged exposures (Rowe VK & Wolf MA: Glycols, in: Clayton GD & Clayton FE (Eds), Pattys Industrial Hygiene and Toxicology, 3rd ed, Vol 3. John Wiley & Sons, New York, NY, 1982 (MEDITEXT via TOMES).

Eye Irritation
SPECIES: Rabbit
RESULTS: Moderately irritating
REFERENCE SOURCE: NEUBER GES.M.B.H. WIEN
(289) "Sbornik Vysledku Toxikologickeho Vysetreni Latek A Pripravku," J.V. Marhold, Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia; -,37,1972 [IUCLID 2000]

Classification STOT Rep. Exp. 1 Plus
Classification route species:
 
Classification description:
H372: Causes damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
Classification key study:

Repeated dose toxicity

Oral Route
Primary Organ Effected: Renal toxicity (Kidney)
Secondary Organ(s) Effected: Cardiovascular system (heart/vascular system)
Neurotoxicity (nervous system)
Remark: For humans LDLO has been reported to be 1560 mg/kg. Acute poisoning with EG includes central nervous system effects, cardiopulmonary effects usually attributed to metabolic acidosis, and finally renal failure. Neurological complications involving the facial nerves with visual impairments have occurred after EG ingestion by a human. In human EG poisonings ethanol/alkali/diuretic infusion antidotal treatment has been useful.
Source: DOW Europe Horgen Hoechst AG Frankfurt/Main
(226) Rowe, Wolf (1982): "Glycols" in: Pattys Industrial Hygiene and Toxicology, GD Clayton and FE Clayton (eds.), third edition, John Wiley & Sons, New York, pp 3817-32 (IUCLID 2000)
Species: rat Sex: no data
Strain: no data
Route of admin.:
Exposure period: 2, 6 or 16 weeks
Frequency of treatment: daily diet ad libitum
Post. obs.
period: no data
Doses: 35, 71, 180, 715 mg/kg (male) and 38, 85, 185, 1128 mg/kg
(female)
Control Group: yes
NOAEL: > 71 - 85 mg/kg bw
LOAEL: = 180 - 185 mg/kg bw
Method: other: not specified
Year: 1974 GLP: no
Test substance: no data
Result: In the two highest dose groups EG affected kidneys, induced oxaluria and oxalate deposition. At the highest EG concentration kidney weights were increased and kidney
function was affected. Male rats (NOEL=71 mg/kg/d, LOEL=180 mg/kg/d) were more susceptible to EG than female rats (NOEL=85 mg/kg/d, LOEL=185 mg/kd/d).
Source: DOW Europe Horgen Hoechst AG Frankfurt/Main DOW Europe, Horgen (Switzerland) Hoechst AG Frankfurt/Main Clariant GmbH Frankfurt am Main
(306) Gaunt et al. (1974): Res. Rep. No. 4 (HOE 74.0470) (IUCLID 2000)